| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9020949 | Vascular Pharmacology | 2005 | 4 Pages |
Abstract
In our quest for comprehensive protection of ischemic myocardium, both basic and clinical studies have lead us to examine signal transduction pathways involved in ischemia-reperfusion injury for potential therapeutic targets. In this review, we have highlighted the importance of the JAK-STAT pathway in modulating ischemia-reperfusion injury. The mechanisms linking glucose metabolism, angiotensin II, with JAK-STAT pathway in ischemic injury are explored in this review. Clearly, the studies discussed in this review provide rationale for the design and synthesis of selective blockers of JAK-STAT pathway as potential therapeutic adjuncts in protecting ischemic myocardium.
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Authors
Radha Ananthakrishnan, Kellie Hallam, Qing Li, Ravichandran Ramasamy,