Article ID Journal Published Year Pages File Type
9021134 International Congress Series 2005 6 Pages PDF
Abstract
Near Infrared Spectroscopy (NIRS) can accurately predict burn wound depth in human subjects. An independent observer classified the acute burn injury into depths based on a visual assessment. Phase I (n = 16) included superficial (n = 8) and full thickness (n = 8) burns while phase II (n = 19) consisted of superficial partial (n = 5) and deep partial thickness (n = 14) injuries. Biopsies were acquired at the time of surgery. NIRS data was collected from a burn and non-burned control site. Statistical significance was achieved using pairwise t-tests if p-value < 0.05. In phase I, superficial burns demonstrated increased oxygen saturation (4.8%, p < 0.05%) and total hemoglobin (91.3%, p < 0.05). Full thickness burn wounds demonstrated decreased oxygen saturation (79.1%, p < 0.05) and total haemoglobin (77.5%, p < 0.05). In phase II, comparing visual assessment with NIRS data, there was an increase in oxygen saturation (3.65%, p < 0.05) and total haemoglobin (15.83%, p < 0.05) in superficial partial thickness burns. In contrast, deep partial thickness burns displayed a decrease in oxygen saturation (17.65%, p < 0.05) and an increase in total haemoglobin (5.07%, p < 0.05). Statistical significance was achieved when comparing NIRS to histopathology and time to wound healing (p < 0.05). This study supports the use of NIRS as a method to objectively determine burn depth.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology
Authors
, , , , , , , ,