Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9021468 | International Congress Series | 2005 | 4 Pages |
Abstract
New binding site of amobarbital in ion pore of resting state nicotinic acetylcholine receptor was found. Amobarbital bound to inside of ion pore, Thr255 of α subunit, which at M2-2â² serine ring. Distance between carbonyl oxygen of the barbital ring and hydroxyl radical of Thr255 was 2.6 Ã
forming hydrogen bond.
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Authors
Tomoyoshi Seto, Shuichi Nosaka,