| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9021526 | International Congress Series | 2005 | 4 Pages |
Abstract
Rapid solution exchange techniques were used to characterize 5-hydroxytryptamine type 3A (5-HT3A) receptor function. The 5-HT3A receptor agonists 5-HT and dopamine were found to have distinct effects on activation, deactivation, and desensitization. Although isoflurane does not enhance submaximal 5-HT-evoked currents or reduce the receptor's agonist EC50 for current activation, it significantly accelerates the rates of activation, deactivation, and desensitization. This acceleration may produce important changes in 5-HT3A receptor-mediated currents in synapses where agonist exposure is brief.
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Authors
D.E. Raines, D. Rusch, P.A. Davies,