Article ID Journal Published Year Pages File Type
9028107 Chemico-Biological Interactions 2005 10 Pages PDF
Abstract
There is no direct evidence that hysteresis plays a role in BChE function(s). However, the “new view” of protein dynamics proposes that proteins are normally in equilibrium between pre-existing, functional and non-functional conformers; and that binding a ligand to the functional form shifts that equilibrium towards the functional conformation. Therefore, a physiological or toxicological relevance for the hysteresis in BChE cannot be ruled out.
Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
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