Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9028107 | Chemico-Biological Interactions | 2005 | 10 Pages |
Abstract
There is no direct evidence that hysteresis plays a role in BChE function(s). However, the “new view” of protein dynamics proposes that proteins are normally in equilibrium between pre-existing, functional and non-functional conformers; and that binding a ligand to the functional form shifts that equilibrium towards the functional conformation. Therefore, a physiological or toxicological relevance for the hysteresis in BChE cannot be ruled out.
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Authors
Patrick Masson, Lawrence M. Schopfer, Marie-Thérèse Froment, Jean-Claude Debouzy, Florian Nachon, Emilie Gillon, Oksana Lockridge, Anna Hrabovska, Boris N. Goldstein,