Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9028583 | Chemico-Biological Interactions | 2005 | 6 Pages |
Abstract
We have evaluated the use of S-PMA as a biomarker, using a commercially available analytical service, in a multicentre European study of populations exposed to varying levels of benzene, in Italy (Milan, Genoa) and in Bulgaria (Sofia). These were filling station attendants, urban policemen, bus drivers, petrochemical workers and referents (a total of 623 subjects). S-PMA was measured at the end of the work shift by an immunoassay procedure. Urinary benzene (in Milan only) and the benzene metabolite trans,trans-muconic acid (t,t-MA) were measured before and after the work shift. Air-borne benzene was measured as a monitor of exposure. Urinary benzene was the most discriminatory biomarker and showed a relationship with airborne benzene at all levels of exposure studied (including groups exposed to <0.1 ppm benzene), whereas t,t-MA and S-PMA, as determined by immunoassay, were suitable only in the highest exposed workers (petrochemical industry, geometric mean 1765 μg/m3 (0.55 ppm) benzene). All three biomarkers were positively correlated with smoking as measured by urinary cotinine).
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Peter B. Farmer, Balvinder Kaur, Jonathan Roach, Len Levy, Dario Consonni, Pietro A. Bertazzi, Angela Pesatori, Silvia Fustinoni, Marina Buratti, Matteo Bonzini, Antonio Colombi, Todor Popov, Domenico Cavallo, Arianna Desideri, Federico Valerio,