| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9030059 | Environmental Toxicology and Pharmacology | 2005 | 7 Pages |
Abstract
The overrepresentation of atypical parkinsonism on Guadeloupe and Guam could be related to the consumption of plants containing (simultaneously) isoquinoline derivates which are toxic for dopaminergic neurons and inhibitors of the mitochondrial respiratory chain such as acetogenins. This hypothesis is in keeping with epidemiologic data and experimental studies showing neuronal loss after exposure to isoquinolines or acetogenins.
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Authors
Dominique Caparros-Lefebvre, John Steele,