| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9032200 | NeuroToxicology | 2005 | 7 Pages |
Abstract
Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinum toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals.
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Authors
Carlotta Grumelli, Claudia Verderio, Davide Pozzi, Ornella Rossetto, Cesare Montecucco, Michela Matteoli,