Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9034003 | Reproductive Toxicology | 2005 | 9 Pages |
Abstract
In fetal testes, Leydig cells were found in large clusters containing AMH positive Sertoli cells. At GD 21, seminiferous chords appeared enlarged with an apparently increased number of gonocytes. However, proliferation of gonocytes did not appear increased. A few animals had a high number of TUNEL positive apoptotic cells in degenerating seminiferous tubules at PND 22 and 190, whereas most exposed animals had low levels of germ cell apoptosis at GD 21, PND 22 or PND 26, as evaluated by DNA laddering, TUNEL staining, Caspase-3 immunohistochemistry and Caspase-3 activity measurement. No differences between DEHP and DEHPÂ +Â DEHA exposed groups were observed.
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Authors
Julie Borch, Majken Dalgaard, Ole Ladefoged,