| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9034482 | Toxicology | 2005 | 7 Pages |
Abstract
Treatment with PCB: (1) decreased the extracellular dopamine level in rat striatum, (2) increased p-nNOS expression both in rat striatal tissue and in CATH.a cells, (3) reduced the cell viability of, and (4) increased LDH release by CATH.a cells. However, Vitamin E showed a protective effect against PCB-induced toxicity and downregulation of the extracellular dopamine level. These results indicate that Vitamin E may have neuroprotective effects by inhibiting PCB-induced nNOS phosphorylation.
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Jae Suk Yun, Han Kwang Na, Ki-Sook Park, Yun Hee Lee, Eun Yeob Kim, Sung Yong Lee, Joo-Il Kim, Ju-Hee Kang, Dong Sup Kim, Ki Hwan Choi,