Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9034805 | Toxicology | 2005 | 8 Pages |
Abstract
The data show different effectiveness of the oximes investigated in reactivation of muscle AChE and recovery of NMT after inhibition by paraoxon. Although an increase in muscle force by the oximes was accompanied by a measurable increase in AChE activity only in the case of obidoxime, the plot of muscle force against AChE activity as well as lacking evidence for a direct effect and adaptive processes indicate that reactivation of the enzyme is the main mechanism of NMT recovery. In agreement, in presence of AChE inhibitory concentrations of paraoxon during reactivation a reduced effectiveness of oximes was found.
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Authors
Horst Thiermann, Peter Eyer, Franz Worek, Ladislaus Szinicz,