Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9035155 | Toxicology | 2005 | 10 Pages |
Abstract
Charles-River mice were distributed into four groups: Control (C), exercise (EX), MDMA treated (M), and M + EX. The treated animals received an i.p. injection (10Â mg/kg) of MDMA (saline for C and EX), and the exercise consisted of a 90Â min level run at a velocity of 900Â m/h, immediately after the MDMA or saline administration. Body temperature was recorded every 30Â min via subcutaneous implanted transponder. Animals were sacrificed 1.5, 25.5, and 49.5Â h after i.p. injection and the soleus muscles were removed and processed for light and electron microscopy. The MDMA-treated animals showed a significant increase in body temperature (similar in M and M + EX groups), reaching the peak 90Â min after i.p. administration; their temperature remained higher than control for more than 5Â h. The EX group evidenced a similar and parallel, yet lower temperature increase during exercise and recovery. Morphological signs of damage were rarely encountered in the EX group; they were more pronounced in M group and even aggravated in M + EX group. In conclusion, MDMA and exercise per se increased body temperature but in conjunction did not have a cumulated effect. However, ecstasy and concomitant physical activity might severely accumulate with regard to skeletal muscle toxicity and may lead to rhabdomyolysis.
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Authors
José A. Duarte, Anabela Leão, José Magalhães, António Ascensão, Maria L. Bastos, Francisco L. Amado, Laura Vilarinho, Dulce Quelhas, Hans J. Appell, Félix Carvalho,