Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9035188 | Toxicology | 2005 | 14 Pages |
Abstract
In these optimised conditions, a panel of irritants and potency-graded sensitizers was used to assess the performance of the modified method. IFN-γ production was used as a positive control. For each compound, a dose-response was performed and stimulation indexes (SI) were determined. Effective concentrations (EC) for each sensitizers were then extracted and compared to the literature data of the regular LLNA. The IL-2-based LLNA showed similar performances at both qualitative and quantitative levels compared to regular LLNA.
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Authors
Philippe Azam, Jean-Luc Peiffer, Jean-Claude Ourlin, Pierre-Antoine Bonnet, Marie-Hélène Tissier, Laurence Vian, Isabelle Fabre,