Article ID Journal Published Year Pages File Type
9036492 Toxicology Letters 2005 7 Pages PDF
Abstract
Semicarbazide was tested for genotoxicity. In this study, we present results from the flow cytometer-based micronucleus assay in peripheral blood of mice. Male CBA and Balb/C mice were intraperitoneally (i.p.) injected with semicarbazide (hydrochloride). The doses were: 0, 40, 80, 120 mg/kg body weight. Blood samples were collected and the frequency of micronucleated polychromatic erythrocytes, fMPCE, and the cell proliferation, %PCE, was determined. In order to further increase the sensitivity of the test for agents with an aneugenic property, also the fMPCE restricted to micronuclei containing a high mean DNA content, was measured. Neither of the different analyses disclosed any adverse effect in either of the two mouse strains.
Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
Authors
, ,