Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9037046 | Toxicology Letters | 2005 | 11 Pages |
Abstract
Bisphenols are a class of compounds that exhibit a broad spectrum of antimicrobial activity. One of the most widely used member of this group is triclosan (TRN). TRN is a synthetic, non-ionic, broad-spectrum antimicrobial agent, which is incorporated into several products, including hand soaps and detergents and those of skin care and oral hygiene. The effects of TRN on mitochondrial respiratory parameters and the inner mitochondrial membrane potential (ÎΨ) are described. That of TRN (up to 60 nmol mgâ1 protein) on isolated liver mitochondria decreased oxygen consumption of state 3 respiration, as well as ÎΨ, but increased oxygen consumption of state 4 respiration, characteristic of an uncoupler effect. Analysis of segments of the respiratory chain suggested that the TRN inhibition site is located between complexes II and III. Mitochondrial swelling, energized or driven by the K+ diffusion potential using valinomycin, was also inhibited by TRN, the former being completely inhibited at concentrations greater than 10 nmol TRN mgâ1 protein, suggesting that it is also able to interfere with fluidity of the inner mitochondrial membrane. These results suggest that, besides its antibacterial effect, TRN can also impair the mitochondrial function of animal cells.
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Authors
Ana Paula Negrelo Newton, Silvia Maria S.C. Cadena, Maria Eliane Merlin Rocha, Eva Gunilla Skäre Carnieri, Maria Benigna Martinelli de Oliveira,