Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9037068 | Toxicology Letters | 2005 | 10 Pages |
Abstract
The effects of stress on the potential reproductive toxicity of long-term exposure to uranyl acetate dihydrate (UAD) were assessed in adult male rats. Six groups of animals were given UAD at 10, 20, and 40Â mg/kg/day in the drinking water during 3 months. Animals in three of these groups were also subjected to restraint for 2Â h/day during the same period. Control groups included restrained and unrestrained male rats not exposed to UAD. To evaluate the fertility, male rats were mated with untreated females for 2 weeks. Although body weight was not affected by uranium at any dose, there was a significant (not dose-related) decrease in the pregnancy rate. Moreover, spermatid number/testis was significantly decreased by uranium administration. Histopathological examination of the testes in rats killed after 3 months of treatment revealed few differences in the tubule and interstitial alterations (focal atrophy, binucleated cells) between control and uranium-exposed animals. The results of this investigation show that at the current UAD doses, restraint stress did not enhance the uranium-induced adverse effects on reproduction in male rats.
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Authors
Victoria Linares, M. Luisa Albina, Montserrat Bellés, Emilio Mayayo, Domènec J. Sánchez, José L. Domingo,