A balanced lipid emulsion-A new concept in parenteral nutrition

A new lipid emulsion (SMOFlipid®) based on soybean oil, medium-chain triglycerides, olive oil and fish oil is characterised by a well-balanced fatty acid pattern, an optimal ω-6/ω-3 fatty acid ratio as well as an enhanced vitamin E content. SMOFlipid® was tested for efficacy, safety and clinical tolerance in healthy subjects and patients and compared with a standard soybean oil emulsion. The results of the clinical studies indicate that SMOFlipid® is safe and well tolerated. Administration of the new emulsion demonstrated controlled triglyceride concentrations and well preserved liver function. Furthermore, SMOFlipid® infusion modulated fatty acid pattern in plasma and cell membrane phospholipids. A rise in EPA- and DHA-derived lipid mediators and maintenance of an adequate vitamin E status could be demonstrated, resulting in a favourable effect on the length of hospital stay in surgical patients receiving SMOFlipid®.