Efficacy of Zoniporide, an Na/H Exchange Ion Inhibitor, for Reducing Perioperative Cardiovascular Events in Vascular Surgery Patients

Conclusions: The results fail to demonstrate the efficacy of zoniporide in reducing the proportion of patients at high risk undergoing noncardiac vascular surgery who experience a composite cardiovascular endpoint, which led the corporate sponsor to stop enrollment early on the basis of a futility analysis of the chance of demonstrating efficacy with a larger sample size.