| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9104382 | Bone | 2005 | 6 Pages |
Abstract
Interleukin (IL)-6 has long been considered as an osteoresorptive factor. However, recent data indicate that IL-6 could influence bone formation in conditions of increased bone turnover. In this paper, the effects of IL-6 and its soluble receptor on osteoblast proliferation, differentiation and apoptosis are readdressed. A brief summary of IL-6 signaling after binding to its receptor is provided and hypotheses concerning IL-6 and the central control of bone formation are also highlighted.
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Authors
Nathalie Franchimont, Sylvie Wertz, Michel Malaise,