| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9107783 | Current Opinion in Genetics & Development | 2005 | 7 Pages |
Abstract
The Ras and Rho GTPases contribute to the initiation and progression of cancer by subverting the normal regulation of specific intracellular signalling pathways. As a result, Ras and Rho play significant roles in the development of numerous aspects of the malignant phenotype by promoting cell cycle progression, resistance to apoptotic stimuli, neo-vascularisation and tumour cell motility, invasiveness and metastasis. With these GTPases contributing at so many levels, they are appealing targets for the development of cancer chemotherapeutic agents.
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Authors
Katharine Walker, Michael F Olson,