| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9109364 | Placenta | 2005 | 5 Pages |
Abstract
Ubiquitin carboxyl-terminal hydrolase-L1 (UCH-L1) is a restrictedly expressed enzyme in neural and reproductive tissues, and it is considered to have a significant role in reproduction. In the present study, we investigated the localization of UCH-L1 in placenta of cynomolgus monkeys (Macaca fascicularis). UCH-L1 protein was detected in cytotrophoblasts of chorionic plate and villi, and decidual cells of decidua basalis in cynomolgus monkey placenta, and the amount of UCH-L1 protein in whole placenta increased as pregnancy progressed. These results supported that UCH-L1 is necessary for placental and fetal development in primate placenta. This is the first report to demonstrate the presence of UCH-L1 in primate placenta, and the cynomolgus monkey may be a useful model for the study of the functions of the ubiquitin-proteasome system in human pregnancy.
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Authors
S. Sekiguchi, A. Takatori, T. Negishi, J. Kwon, T. Kokubo, Y. Ishii, S. Kyuwa, Y. Yoshikawa,