Article ID Journal Published Year Pages File Type
9110927 Cytokine 2005 6 Pages PDF
Abstract
Data suggest that hydroxyurea up-regulates IL-13 secretion in anti-CD3-activated lymphocytes through gene activation but not by altered cell proliferation. Increased IL-13 secretion may contribute to unresponsiveness of certain SCD patients to hydroxyurea. The potential benefit of zileuton in the management of vasoocclusion is discussed.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology
Preview
Differential effects of hydroxyurea and zileuton on interleukin-13 secretion by activated murine spleen cells: Implication on the expression of vascular cell adhesion molecule-1 and vasoocclusion in sickle cell anemia
Authors
, , , , , , , ,