| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9114628 | Growth Hormone & IGF Research | 2005 | 9 Pages |
Abstract
An extensive reduction of fat mass did not improved signs of insulin resistance in GH treated old obese rats. The molecular events associated with GH treatment included tissue specific changes in the function of IR and IRS-1 suggesting the liver to be the primary site of insulin resistance. Furthermore, the association of IRS-1with JAK-2 in the course of GH signaling could present a mechanism for GH to directly induce insulin resistance.
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Authors
T. Johansen, C. Laurino, A. Barreca, K. Malmlöf,