Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9115137 | Journal of Diabetes and its Complications | 2005 | 4 Pages |
Abstract
The aim of the present work was an examination of IL-18 concentration in the sera of elderly DM2 patients with nonproliferative retinopathy and age-matched control people and an estimation whether this cytokine plays pro- or anti-angiogenic role in in vivo angiogenic activity of their sera in mice cutaneous angiogenesis test. Recombinant human IL-18 injected intradermally to murine skin induced significant neovascular reaction. DM2 patients sera contained higher concentration of IL-18 and induced stronger neovascular reaction in mice skin than did the sera of corresponding control people. Sera from both groups of people after neutralization with antihuman IL-18 antibodies lost substantial part of their angiogenic activity.
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Authors
Piotr SkopiÅski, Ewa Rogala, Barbara Duda-Król, Anna LipiÅska, Ewa Sommer, Joanna Chorostowska-Wynimko, Jerzy Szaflik, Iwona Partyka, Ewa SkopiÅska-Różewska,