Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9119074 | Nutrition Research | 2005 | 10 Pages |
Abstract
Short-term severe copper deficiency has been shown to significantly reduce acetylcholine (Ach)-induced vascular smooth muscle relaxation. The current study was designed to examine the long-term relationship of marginal dietary Cu to vasoreactivity. Male adult rats were fed a purified diet with adequate (6.0 μg) or marginal (3.0 or 1.5 μg) Cu/g diet for 6 months. Luminal diameter changes were measured in isolated resistance arterioles. Liver and kidney Cu concentrations were used as indices of Cu status. The results showed a significant decrease in kidney Cu in the 1.5-μg group compared with the adequate controls but no effect on liver Cu. There was a significant correlation between dilation to 10â6 mol/L Ach and kidney Cu but no relationship between Cu status and 10â5 mol/L norepinephrine-induced constriction or flow-induced dilation. There was also no dietary effect on baseline vessel tone or dilator capacity. The data are the first to establish a linear relationship between Ach-induced vasodilation and systemic Cu status in a mature long-term model of marginal Cu deficiency.
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Authors
Jeff C. Falcone, Jack T. Saari, Y. James Kang, Dale A. Schuschke,