Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9121998 | FEMS Microbiology Letters | 2005 | 6 Pages |
Abstract
Antifungal activity of histatin 3 against two Candida albicans clinical isolates was determined in assays containing rabbit submandibular gland saliva. Histatin 3 inhibited the cell growth and germination of both isolates dose-dependently (10-100 μg mlâ1) with maximum inhibition occurring after 60 min incubation. Adding fresh histatin 3 after 60 min caused further reduction in the viable cell count. Higher histatin 3 concentrations (50-100 μg mlâ1) and prolonged exposure to peptide were required to inhibit germination. Histatin 3 was rapidly degraded in rabbit submandibular gland saliva and this may explain why fresh addition of histatin 3 increases candidacidal activity.
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Authors
Hisako Yamagishi, Deirdre H. Fitzgerald, Tin Sein, Thomas J. Walsh, Brian C. O'Connell,