Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9126873 | Gene | 2005 | 10 Pages |
Abstract
In this study we report the characterisation of a new splice variant, here denominated splice variant 4 (accession number AF258557) of the human Multiple Ankyrin repeats Single KH domain (hMASK) (accession number AF521882) and the hMASK-4E-Binding Protein 3 Alternative Reading Frame (hMASK-BP3ARF) (accession number AF521883), containing a number of ANK-repeat motifs. Ankyrin (ANK) repeat-containing proteins carry out a wide variety of biological activities and are involved in processes, such as cell differentiation and transcriptional regulation. The present study reports the computer analysis of these splice variant cDNAs and their broad mRNA expression in different normal human tissues and cancer cell lines. An upregulation of the splice variant mRNAs expression was observed after HL-60 and erythroblast differentiation. The upregulation of splice variant 4 mRNA was considerably higher than those of the other variants, during erythroid differentiation.
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Genetics
Authors
Adriana da Silva Santos Duarte, FabÃola Traina, Patricia M. Bergamo Favaro, Daniela Sanchez Bassères, Iara Campos de Carvalho, Samuel de Souza Medina, Fernando Ferreira Costa, Sara Teresinha Olalla Saad,