Sex-linked recombination variation and distribution of disease-related genes

Our study demonstrates that the use of different data sets and tools have only a local impact on the distribution of genetic recombination hot zones and provides evidence for gender-specific differences in enrichment in disease-related loci in relation with recombination frequency. Automation of such analyses and extension to the entire human genome will be required in order assess the general character of these observations and to advance in the understanding of genome-wide recombination patterns to help the process of identifying disease-causing genes.