Article ID Journal Published Year Pages File Type
9127328 Gene 2005 7 Pages PDF
Abstract
We discuss recent developments in the modeling of negative autoregulated genetic networks. In particular, we consider the temporal evolution of the population of mRNA and proteins in simple networks using rate equations. In the limit of low copy numbers, fluctuation effects become significant and more adequate modeling is then achieved using the master equation formalism. The analogy between regulatory gene networks and chemical reaction networks on dust grains in the interstellar medium is discussed. The analysis and simulation of complex reaction networks are also considered.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Genetics
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