Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9131902 | Genomics | 2005 | 8 Pages |
Abstract
Monosomy 7 and deletions of 7q are recurring leukemia-associated cytogenetic abnormalities that correlate with adverse outcomes in children and adults. We describe a 2.52-Mb genomic DNA contig that spans a commonly deleted segment of chromosome band 7q22 identified in myeloid malignancies. This interval currently includes 14 genes, 19 predicted genes, and 5 predicted pseudogenes. We have extensively characterized the FBXL13, NAPE-PLD, and SVH genes as candidate myeloid tumor suppressors. FBXL13 encodes a novel F-box protein, SVHis a member of a gene family that contains Armadillo-like repeats, and NAPE-PLD encodes a phospholipase D-type phosphodiesterase. Analysis of a panel of leukemia specimens with monosomy 7 did not reveal mutations in these or in the candidate genes LRRC17, PRO1598, and SRPK2. This fully sequenced and annotated contig provides a resource for candidate myeloid tumor suppressor gene discovery.
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Authors
Nicole P. Curtiss, Jeannette M. Bonifas, Jennifer O. Lauchle, Jason D. Balkman, Christian P. Kratz, Brooke M. Emerling, Eric D. Green, Michelle M. Le Beau, Kevin M. Shannon,