Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9132067 | Genomics | 2005 | 15 Pages |
Abstract
The carcinoembryonic antigen (CEA) family comprises a still actively evolving populous group of proteins that are involved in controlling tissue homeostasis, immune responses, and host/pathogen interactions. The genes identified to date in rodents and primates exhibit low sequence similarity and an extremely variable domain composition. Among the 22 murine Cea-related genes, only for Ceacam1 has an ortholog been assigned. To identify all CEA-related genes in mouse, rat, and human we undertook genome-wide analyses. Eight of 9 new expressible genes (Ceacam12-Ceacam20) could be located within the â¼6.5-Mb murine Cea locus. Five of the genes were rodent-specific (Ceacam12-Ceacam15 and Ceacam17). Surprisingly, for the remaining 4 (Ceacam16 and Ceacam18-Ceacam20) orthologs could be detected in all three genomes at syntenic locations. Gene-specific reverse transcription/PCR analyses of total RNA from 31 murine adult, placental, and embryonic tissues as well as tumors revealed very distinct expression patterns, suggesting diversified functions within the CEA family.
Keywords
IGCSimian Virus 40 large tumor antigenCeacamTh1, Th2MHVITAMIGVMMTVITIMCeAcarcinoembryonic antigenSV40 T antigenExpressionimmunoreceptor tyrosine-based inhibition motifimmunoglobulin cytoplasmic domaintransmembrane domainNK cellNatural killer cellEvolutionimmunoreceptor tyrosine-based activation motifMouse mammary tumor virusMouse hepatitis virusPSG
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Authors
Roland Zebhauser, Robert Kammerer, Andreas Eisenried, Andrew McLellan, Tom Moore, Wolfgang Zimmermann,