Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9140145 | Molecular and Biochemical Parasitology | 2005 | 9 Pages |
Abstract
The natural insertion of the repetitive element short interspersed repetitive element (SIRE) in one of the HX1 polypyrimidine tracts decreases the translated protein level by 40%. In this report, we demonstrated that this reduction is a consequence of a decrease of five-fold in the level of processed mRNA balanced by an increased efficiency of translation due to the inclusion of a 38 nt SIRE specific sequence in the 5â²UTR of the mRNA.
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Authors
Claudia P. Ben-Dov, Mariano J. Levin, MartÃn P. Vázquez,