| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9140153 | Molecular and Biochemical Parasitology | 2005 | 8 Pages |
Abstract
None of the alleles generated in this study was as resistant to chlorcycloguanil as the common quadruple mutant, 51I/59R/108N/164L. In addition, selection of high levels of chlorcycloguanil resistance in parasites that carry the 51I/59R/108N allele will require two directed steps, a change from 108N to 108T followed by a mutation from A16 to 16V. The resulting allele, 16V/51I/59R/108T is highly resistant to chlorcycloguanil, but 200-fold more sensitive to pyrimethamine than the 51I/59R/108N allele.
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Authors
Sonia Y. Hunt, Brian B. Rezvani, Carol Hopkins Sibley,