Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9146709 | Clínica e Investigación en Arteriosclerosis | 2005 | 7 Pages |
Abstract
The chicken is useful and suitable as an animal model of hepatic steatosis induced by an atherogenic diet. Two methods of assessment are described: macroscopic and microscopic analysis. It was concluded that macroscopic evaluation rapidly identifies the effect of diet; atorvastatin showed a beneficial effect, although this was not statistically significant. Histological analysis (by evaluation of lipidic deposits) provided a more detailed classification of the grades of lesion, especially in intermediate grades. The histological analysis showed a decrease in the severity of induced hepatic lesions in atorvastatin-treated groups. The combination of the two evaluation methods (macroscopic and microscopic) was useful for determining the grades of severity of hepatic steatosis.
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Authors
A. MartÃn-Castillo, B. GarcÃa-Pérez, I. Ayala, G. Adánez, J.V. Ortega, M.T. Sánchez, M.T. Castells,