Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9152351 | Respiratory Physiology & Neurobiology | 2005 | 12 Pages |
Abstract
Our observations lead us to speculate that episodic hypoxia - a consequence of periodic airway occlusion - is responsible for progression of OSA through impairment of the neural control systems that regulate upper airway patency and through altered respiratory muscle contractile function, leading to the establishment of a vicious cycle of further airway obstruction and hypoxic insult that chronically exacerbates and perpetuates the condition. We conclude that chronic intermittent hypoxia/asphyxia contributes to the pathophysiology of sleep-disordered breathing.
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Authors
Aidan Bradford, Michelle McGuire, Ken D. O'Halloran,