| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9160667 | Cardiovascular Pathology | 2005 | 9 Pages |
Abstract
The transforming growth factor β (TGFβ) family of cytokines exert pleiotropic effects upon a wide variety of cell types. TGFβ1 has been demonstrated to be of fundamental importance in the development, physiology and pathology of the vascular system. As the role of TGFβ1 in these processes becomes clearer, influencing its activity for therapeutic benefit is now beginning to be investigated. This review presents an overview of the role of TGFβ1 in the vasculature. The cellular and extracellular biology of the TGFβ family is first addressed, followed by an overview of the function of TGFβ1 during vascular development, atherogenesis, hypertension, and vessel injury.
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Authors
Jonathan Ghosh, Michael O. Murphy, Neill Turner, Nadeem Khwaja, Anastassi Halka, Cay M. Kielty, Michael G. Walker,