Phenotypic Characterization of Pulmonary Arteries in Normal and Diseased Lung

Vascular endothelium is a continuous cell layer lining the cardiovascular system and serves as an interface between blood and the vascular wall tissue. Although the basic morphology of endothelial cells is similar in blood vessels of different organs and tissues, there is a great heterogeneity in endothelial cell types based on structural, metabolic, and developmental differences within each organ, particularly in the pulmonary vasculature. Current data about the usage of different markers for the immunohistochemical detection of endothelial cells in lung tissue are summarized, and functional aspects of caveolin expression after lung injury and in pulmonary hypertension are discussed.