Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9164613 | Chest | 2005 | 9 Pages |
Abstract
These results confirm that apoptotic hyperplastic epithelial cells are present in patients with IPF and that the expression of p53, p21, bax, and caspase-3 appears to be up-regulated and that of bcl-2 down-regulated in these cells. The increased expression of proapoptotic molecules in epithelial cells in IPF may be involved in the inadequate and delayed reepithelialization, which in turn contributes to fibroblast proliferation.
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Authors
Plataki MD, Koutsopoulos MD, Darivianaki BS, Delides MD, PhD, Siafakas MD, PhD, FCCP, Bouros MD, FCCP,