Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome

Our data demonstrate disparate response of Brugada patients to flecainide and ajmaline, with a failure of flecainide in 7 of 22 cases (32%). Greater inhibition of Ito by flecainide may render it less effective. These observations have important implication for identification of patients at risk for sudden death.