Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9173762 | Journal of Vascular Surgery | 2005 | 7 Pages |
Abstract
Postthrombotic syndrome remains a significant clinical problem after deep venous thrombosis (DVT), but the cellular and molecular mechanisms involved in thrombus resolution and vein wall fibrosis remain undefined. Matrix metalloproteinase (MMP) enzymes are critical to cell migration and matrix breakdown. We identify gene transcription and activity of two MMP isoforms, MMP-2 and MMP-14 (membrane type MMP 1, MT1-MMP) in the resolution phase of experimental DVT and in thrombin-treated endothelial cells. These studies define new proteases potentially important to resolution of DVT and development of postthrombotic syndrome.
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Authors
Sia BA, Jackie G. BA, David H. MD, Rajabrata MD, PhD,