Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9174615 | Journal of Vascular Surgery | 2005 | 5 Pages |
Abstract
A 47-year-old man with heterozygous factor V Leiden disorder and intermittent hyperhomocysteinemia developed spontaneous acute popliteal artery thrombosis. Homocysteine levels were above normal limits at presentation. Intra-arterial thrombolysis was used successfully to treat the acute thrombosis; long-term treatment included anticoagulation, folic acid, and risk factor modification. Although factor V Leiden is strongly associated with deep venous thrombosis, additional cofactors such as hyperhomocysteinemia may predispose to an increased risk of acute arterial thrombosis in areas of pre-existing peripheral arterial disease.
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Authors
Cameron BS, Lee E. MD, Richard J. MD, Alan MD, PhD,