| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9175041 | Journal of Vascular Surgery | 2005 | 12 Pages |
Abstract
Abdominal aortic aneurysms (AAAs) are an important cardiovascular disease, but the genetic and environmental risk factors, which contribute to individual's risk to develop an aneurysm, are poorly understood. Histologically, AAAs are characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. We hypothesized that genes involved in these events could harbor changes that make individuals more susceptible to developing aneurysms. This study identified significant genetic associations between DNA sequence changes in tissue inhibitor of metalloproteinase 1 (TIMP1), TIMP3, matrix metalloproteinase 10 (MMP10) and elastin (ELN) genes, and AAA. The results will require confirmation using an independent set of samples. After replication it is possible that these sequence changes in combination with other risk factors could be used in the future to identify individuals who are at increased risk for developing an AAA.
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Authors
Toru MD, Hidenori MD, PhD, Gerard PhD, Moumita MStat, Katrina A.B. PhD, Natzi MD, PhD, Raymond MD, PhD, Gerald L. MD, Claudette BN, MBA, Taijiro MD, PhD, Susan PhD, Helena MD, PhD,