Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9175168 | Journal of Vascular Surgery | 2005 | 6 Pages |
Abstract
This study demonstrates that homocysteine can promote chemotaxis of SMCs through a p38-dependent pathway. To our knowledge, this is the first report that homocysteine may influence SMC chemotaxis. It may be an important mechanism for homocysteine-induced atherogenesis, because the migration of SMCs from the media is believed to play a critical role in progressive intimal thickening. Although homocysteine promotes atherogenesis and thrombosis by a variety of mechanisms, the effects of homocysteine on SMC proliferation and migration might be critical elements that may have potential therapeutic implications, because selective blockade of the p38 pathway is feasible.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Kazumi MD, Nobuyuki MD, Gabriel MD, Tadahiro MD, PhD, Bauer E. MD, PhD,