Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9175345 | Journal of Vascular Surgery | 2005 | 11 Pages |
Abstract
One difficulty in the pharmacologic treatment of atherosclerosis or neointimal hyperplasia leading to restenosis is the multiplicity of activated pathways and thus potential treatment targets. This study demonstrates that shear stress, a hemodynamic force that may be a biologically relevant stimulus to induce vascular pathology, stimulates endothelial cells to secrete PDGF-BB and IL-1α. Both of these mediators stimulate the SMC ERK1/2 pathway to induce migration, a critical event in the pathogenesis of atherosclerosis and neointimal hyperplasia. Therefore, this study suggests a relevant common target pathway in SMC that is amenable to manipulation for clinical treatment.
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Authors
Alan MD, PhD, Akimasa MD, PhD, Faisal MD, Hidenori MD, Bauer E. MD, PhD,