Short-term effects of estrogen, tamoxifen and raloxifene on hemostasis: a randomized-controlled study and review of the literature

Article ID	Journal	Published Year	Pages	File Type
9185522	Thrombosis Research	2005	13 Pages	PDF

Abstract

Estrogen, tamoxifen and raloxifene affected hemostasis favoring procoagulation and impairing anticoagulation. The biochemical effects of the selective estrogen receptor modulators (SERMs) were distinct from those of estrogen and differed only subtly from each other.

Keywords

FXI FVII FVIII APTT CEE vWF FII TAFI PAI-1 APC SERMs Pulmonary embolism hERs antithrombin Women's Health Initiative Estradiol Estrogen Conjugated equine estrogen Estrogen Therapy tamoxifen Venous thrombosis Deep vein thrombosis DVT FIX Relative risk Raloxifene activated partial thromboplastin time body mass index BMI Von Willebrand factor Factor VIII Factor IX Factor VII Factor XI Selective estrogen receptor modulators Heart and Estrogen/Progestin Replacement Study Plasminogen activator inhibitor-1 Thrombin activatable fibrinolysis inhibitor Hormone therapy Hemostasis whi Activated protein C