| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9185525 | Thrombosis Research | 2005 | 7 Pages |
Abstract
Myocardial ischemia induces contact activation and thrombin generation rather than release of tPA and might thus contribute to postoperative thromboembolic complications. Surgery itself and CPB cause activation of coagulation and fibrinolysis as already described. A significant association between FXIIa, FVIIa, F1+2, DD and PPI suggests a relationship between contact activation, thrombin generation, fibrin formation and fibrinolysis.
Keywords
ECCCAFMCPBtPAPPICHDPTCATFPId-dimersF1+2Percutaneous transluminal coronary angioplastyMyocardial ischemiacardiopulmonary bypasscoronary heart diseaseTATELISAEnzyme-linked immunosorbent assayCardiopulmonary bypass surgeryTissue factorContact activationtissue plasminogen activatorprothrombin fragments 1+2Thrombin–antithrombin complexTissue factor pathway inhibitor
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Authors
Gerhard Kalweit, Jürgen Bach, Hanno Huwer, Johannes Winning, Peter Hellstern,