Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9185618 | Thrombosis Research | 2005 | 6 Pages |
Abstract
Fifteen patients (2.09%) had venous thromboembolism (objectively confirmed in 13 patients) in close temporal relationship to the onset of acute leukemia. The incidence of venous thromboembolism was the same in acute myelogenous and lymphoblastic leukemia. In five patients, pulmonary embolism was documented. Venous thromboembolism occurred in all subtypes of acute leukemia, but was most common in promyelocytic leukemia. All but one patient were treated with anticoagulants. No patient died from treatment-related bleedings or venous thromboembolism. Overall, survival, disease-free survival, and remission duration did not differ between the patient groups with and without venous thromboembolism. In contrast to solid tumors, venous thromboembolism before or at diagnosis of acute leukemia is not associated with poor prognosis.
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Authors
Sophie Ziegler, Wolfgang R. Sperr, Paul Knöbl, Stephan Lehr, Ansgar Weltermann, Ulrich Jäger, Peter Valent, Klaus Lechner,