Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9187341 | Brain and Development | 2005 | 5 Pages |
Abstract
In Japan, quite a few patients with spinal muscular atrophy type 1 (SMA type 1) survive with mechanical ventilation. Since a patient with SMA type 1 and continuous artificial ventilation exhibited excessive perspiration and tachycardia, we examined the autonomic functions in three cases of SMA type 1, undergoing mechanical ventilation. Two cases exhibited the common sympathetic-vagal imbalance on R-R interval analysis involving 24-h Holter ECG recordings in addition to an abnormality in finger cold-induced vasodilatation. Furthermore, one case showed blood pressure and heart rate fluctuation with the paroxysmal elevation, and a high plasma concentration of norepinephrine during tachycardia. These findings suggest that autonomic dysfunction should be examined in SMA type 1 patients with long survival, although the pathogenesis remains to be clarified.
Keywords
Related Topics
Life Sciences
Neuroscience
Developmental Neuroscience
Authors
Yasuo Hachiya, Hidee Arai, Masaharu Hayashi, Satoko Kumada, Wakana Furushima, Eiko Ohtsuka, Yasushi Ito, Akira Uchiyama, Kiyoko Kurata,