Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9190260 | Epilepsy & Behavior | 2005 | 13 Pages |
Abstract
In conclusion, BI, which is a measure of the margin of safety and tolerability of drugs in combination and comprises anticonvulsant and neurotoxic measures, was favorable for only one combination (LCZ and ETS at a fixed ratio of 1:3) with a value of 1.39. In contrast, LCZ and CZP constitute an unfavorable combination (BIÂ =Â 0.61-1.01). The combinations of LCZ with PB or VPA do not offer any advantage as assessed by the parameters (BI range: 0.75-0.91) used in this study. However, these conclusions are confounded by the fact that LCZ is associated with significant pharmacokinetic interactions.
Keywords
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Behavioral Neuroscience
Authors
Jarogniew J. Luszczki, Neville Ratnaraj, Philip N. Patsalos, Stanislaw J. Czuczwar,