| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9191206 | Epilepsy Research | 2005 | 4 Pages |
Abstract
Inhibitory postsynaptic currents were measured in CA1 pyramidal cells from chronically epileptic rats (pilocarpine model). Tiagabine, a selective inhibitor of the GABA-uptake transporter 1 prolonged currents equally to cells from control animals. Thus, GABA-uptake has an unaltered impact on inhibitory synaptic efficacy in rats with chronic temporal lobe epilepsy, underlining the rational for the use of GABA-uptake blockers in this condition.
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Authors
Frank Stief, Antje Piechotta, Sigrun Gabriel, Dietmar Schmitz, Andreas Draguhn,